SPANISH NATIONAL CANCER RESEARCH CENTRE
Spanish National Cancer Research Centre
Melchor Fernandez Almagro 3
28029 Madrid, Spain
At the CNIO, world-class basic and translational scientists are working on cancer stem cell-centered projects focussing on stem cell biology, stem cell ageing, and mouse transgenesis with particular emphasis on pancreatic ductal adenocarcinoma. Specifically, a total of five groups at CNIO is working on pancreatic cancer ranging all the way from basic science to clinical investigations. The CNIO has unrestricted access to a nation-wide tumour bank as well as fresh human samples.
The state-of-the-art CNIO building provides a superb infrastructure and outstanding networking capabilities. The animal facility within the CNIO is certainly one of the best in Europe and provides ample space and expertise to establish breeding colonies as well as generation of new genetically modified mouse strains necessary for the proposed project. Therefore, the CNIO harbours a very stimulating environment to successfully seed and advance research activities from basic science to clinical investigations.
The Stem Cell & Cancer Group (Christopher Heeschen)
The goal of the present project is to functionally interrogate transcriptomic data from a large set of pancreatic cancer stem cells in order to systemati¬cally identify, characterise, and validate novel CSC targets for therapeutic intervention. The latter will be done using advanced cellular and animal models for human and mouse pancreatic cancer. Importantly, we have already identified a workable number of putative candidate genes in pancreatic cancer stem cells using hypothesis-driven approaches, for which increasing amounts of functional in vitro data are now emerging. These candidate genes will provide the initial context for the advancing our in vitro and in vivo model systems. These data will later be complemented by unbiased data from comprehensive shRNA screens in cancer stem cells from a diverse cohort of patients with pancreatic ductal adenocarcinoma.